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Canadian Journal of Anesthesia, Vol 30, 635-640, Copyright © 1983 by Canadian Anesthesiologists' Society

Postoperative Malignant Hyperthermia and Dantrolene Therapy

UWE SCHULTE-SASSE MD1, WOLFGANG HESS MD1, and HANS JOACHIM EBERLEIN MD1

1 Department of Anaesthesiology of the Klinikum Charlottenburg, Free University of Berlin, Germany

Address correspondence to: Dr. Schulte-Sasse, Department of Anaesthesiology, Klinikum Charlottenburg, Free University of Berlin, Spandauer Damm 130, 1000 Berlin 19, Germany.

A case of malignant hyperthermia (MH) in a three-year eight-month-old girl is presented. Definite symptoms of MH developed in the awake patient 30 min after termination of anaesthesia which had lasted five hours. This postoperative MH-episode resolved promptly following intravenous administration of dantrolene (2.5 mg·kg-1 initially, followed by 5 mg·kg-1 over 12 hours). Results of serial serum samples revealed a steady increase in creatine kinase (CK) concentration with the highest value being observed at the second day, despite dantrolene therapy. The unusual occurrence of MH in the postoperative period, when the major effects of anaesthesia were no longer an important consideration, is discussed with regard to the "human stress syndrome." The necessity to give this information to people usually not familiar in diagnosing MH (e.g., medical personnel in surgical wards) is stressed.

Key Words: DANTROLENE: therapeutic use • FEVER: occurrence • MALIGNANT HYPERTHERMIA: therapy • POSTOPERATIVE COMPLICATIONS: etiology






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Copyright © 1983 by the Canadian Anesthesiologists' Society.