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Canadian Journal of Anesthesia, Vol 31, 20-23, Copyright © 1984 by Canadian Anesthesiologists' Society

Effect of Age on Epinephrine-Induced Arrhythmias during Halothane Anaesthesia in Pigs

CHALAPATHI C. RAO MD1, STEPHEN F. DIERDORF MD1, THOMAS M. WOLFE MD1, KENNETH A. HASELBY MD1, GOPAL KRISHNA MD1, and RAYMOND R. PARADISE PHD1

1 Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana

Address correspondence to: Stephen F. Dierdorf MD, 1120 South Drive, Fesler Hall 204, Indianapolis, Indiana 46223.

The effect of age on the arrhythmogenicity of epinephrine during halothane anaesthesia was studied in pigs of two different age groups. At a stable alveolar concentration of 0.84 volumes per cent halothane, ventricular arrhythmias could not be elicited in one- to three-day-old pigs by a 100 µg·kg-1 infusion of epinephrine. PVCs were produced in 50- to 55-day-old pigs at a mean epinephrine dose of 9.55 µg·kg-1. Heart rate, systolic blood pressure, and rate-pressure product were significantly higher before and during the epinephrine infusion in the 50- to 55-day-old pigs. It is concluded that there is an age dependent effect upon epinephrine induced arrhythmias during halothane anaesthesia in pigs.

Key Words: ANAESTHETICS, VOLATILE: halothane • HEART, arrhythmia: epinephrine • AGE FACTORS: halothane • ANAESTHESIA, paediatric






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Copyright © 1984 by the Canadian Anesthesiologists' Society.