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Canadian Journal of Anesthesia, Vol 31, 5-12, Copyright © 1984 by Canadian Anesthesiologists' Society

Rate-Pressure Product Correlates Poorly with Myocardial Oxygen Consumption during Anaesthesia in Coronary Patients

EMERSON A. MOFFITT MD1, DHUN H. SETHNA MD1, RICHARD J. GRAY MD1, MICHELE DEROBERTIS RN1, JACK M. MATLOFF MD1, and JOHN A. BUSSELL MD1

1 Department of Anesthesiology and Thoracic and Cardiovascular Surgery, Cedars-Sinai Medical Centre, Los Angeles, California

Address correspondence to: E.A. Moffitt, MD, Sir Charles Tupper Medical Building, University Avenue, Halifax, Nova Scotia, B3H 4H7.

In 26 patients having coronary grafts, haemodynamics, coronary sinus blood flow and the arterio-coronary sinus difference of oxygen content were determined, awake and at four intervals during morphine-oxygen or halothane-oxygen anaesthesia. Rate-pressure product (RPP), triple product (TP) and myocardial oxygen consumption (MVO2) were calculated. The correlation of the two indirect indices to MVO2 were tested by repeated measures and regression analyses. No significant correlations were seen at four of five study times, when outlying data points were appropriately excluded. A pitfall of using more than one data point from each patient in the linear regression analysis is pointed out. In addition to the lack of correlation of RPP to MVO2, RPP was an imprecise predictor of myocardial lactate production and of postoperative infarction.

Key Words: ANAESTHETICS, VOLATILE: halothane • ANAESTHETICS, INTRAVENOUS: morphine • HEART: oxygen consumption, pulse rate, myocardial blood flow






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Copyright © 1984 by the Canadian Anesthesiologists' Society.