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Canadian Journal of Anesthesia, Vol 31, 268-271, Copyright © 1984 by Canadian Anesthesiologists' Society

Reports of Investigation: Tissue Reaction of Morphine Applied to the Epidural Space of Dogs

F. G. KING MD FRCP(C)1, A. D. BAXTER BM BCH FFARCS FRCP(C)1, and G. MATHIESON MB CHB MSC FRCP(C)2

1 Department of Anaesthesia, Health Sciences Centre, Memorial University of Newfoundland, St. John's, Newfoundland
2 Department of Pathology (Dr. Mathieson), Memorial University of Newfoundland, St. John's, Newfoundland

Address correspondence to: Dr. F.G. King, Department of Anaesthesia, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3V6.

Epidural morphine has found increasing popularity in clinical trials for the relief of chronic and postoperative pain relief. This study was conducted to determine if there was any adverse tissue reaction when morphine was applied to the epidural space of dogs. Sixteen dogs were given 0.07 mg.kg-1 of morphine in a volume of 2 cc of normal saline into the epidural space. Gross and microscopic studies of the epidural space, dura, and spinal cord did not show any adverse tissue reaction.

Key Words: ANAESTHETIC TECHNIQUES, EPIDURAL: epidural morphine, tissue reaction






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Copyright © 1984 by the Canadian Anesthesiologists' Society.