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Canadian Journal of Anesthesia, Vol 31, 359-363, Copyright © 1984 by Canadian Anesthesiologists' Society

Reports of Investigation: Premedication with Intramuscular Midazolam: Effect on Induction Time with Intravenous Midazolam Compared to Intravenous Thiopentone or Ketamine

ALAN A. ARTRU MD1, M. SAEED DHAMEE MD2, and ASTRIDE B. SEIFEN MD3

1 Departments of Anaesthesiology, University of Washington School of Medicine, Seattle, Washington
2 The Medical College of Wisconsin, Milwaukee, Wisconsin
3 University of Arkansas for Medical Sciences, Little Rock, Arkansas

Address correspondence to: Dr. A.A. Artru, Department of Anesthesiology, RN-10, University of Washington Medical School, Seattle, WA 98195.

Our study sought to determine whether premedication with intramuscular midazolam would decrease the time to induction of anaesthesia with intravenous midazolam, and if so whether induction of anaesthesia would be as rapid as with thiopentone or ketamine, intravenously. Eighty-nine patients, ASA physical status I or II, received midazolam 0.2 mg·kg-1, thiopentone 3.0 mg·kg-1, or ketamine 2.0 mg·kg-1 intravenously 60-90 min after intramuscular injection of either midazolam 0.07 mg·kg-1 or matching placebo. Time to induction of anaesthesia or the dose required to induce anaesthesia with intravenous midazolam was not decreased by midazolam premedication. Both with or without premedication.

Key Words: ANAESTHETICS, INTRAVENOUS • ketamine, thiopentone • HYPNOTICS: benzodiazepines, midazolam • INDUCTION: anaesthesia • PREMEDICATION: midazolam






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Copyright © 1984 by the Canadian Anesthesiologists' Society.