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Canadian Journal of Anesthesia, Vol 31, 434-438, Copyright © 1984 by Canadian Anesthesiologists' Society

Clinical Reports: Anaphylactic Reaction to Thiopentone: A Case Report

PAUL WESTACOTT MBBS1, P. R. RAMACHANDRAN MBBS, FRCP(C)1, and ZYGMUNT JANCELEWICZ MD FRCP(C) FAAA1

1 Department of Anaesthesia and the Department of Medicine, Allergy Clinic, the Wellesley Hospital in Toronto

Address correspondence to: Dr. P. Ramachandran, Department of Anaesthesia, Wellesley Hospital, 160 Wellesley Street East, Toronto, Ontario. M4Y 1J8.

A 32-year-old female was admitted for a minor elective surgical procedure. Her past history included at least six uneventful general anaesthetics. Anaphylaxis developed shortly following induction of anaesthesia with thiopentone, Innovar and gallamine. Resuscitation was successful but was complicated by ventricular fibrillation. Full recovery followed. Subsequent allergy skin tests revealed hypersensivity to thiopentone. Recommendations for investigation of suspected hypersensitivity to anaesthetic agents are included, as are guidelines for the recognition and treatment of anaphylaxis.

Key Words: COMPLICATIONS: anaphylaxis, thiopentone






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Copyright © 1984 by the Canadian Anesthesiologists' Society.