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Canadian Journal of Anesthesia, Vol 31, 491-496, Copyright © 1984 by Canadian Anesthesiologists' Society

Reports of Investigation: Vecuronium in Renal Failure

D. R. BEVAN MB MRCP FFARCS1, F. DONATI PHD MD1, H. GYASI MB FFARCS1, and A. WILLIAMS MB FFARCS1

1 Departments of Anaesthesia, Royal Victoria Hospital & McGill University, Montreal, Quebec

Address correspondence to: Dr. D.R. Bevan, Department of Anaesthesia, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Que., H3A 1A1.

Neuromuscular blockade during surgery was provided with vecuronium in 24 adult patients in end-stage renal failure and in 21 normal patients who served as controls. Dose response curves were constructed which showed that the effective doses required to produce 50, 90 and 95 per cent neuromuscular blockade in patients with renal failure were 27.5, 43 and 49 µg·kg-1 respectively. These were not significantly different from the doses of 31, 49 and 57 µg·kg-1 in the normal patients. Repeated small doses of 0.01 mg·kg-1 had a significantly longer duration of action and were associated with some cumulation in the renal failure group. Recovery from the block occurred rapidly after neostigmine, was no different in renal failure and was not associated with recurarization. It is concluded that, when given to subjects in renal failure, vecuronium offers advantages over established agents such as shorter duration of action and easy reversibility.

Key Words: NEUROMUSCULAR RELAXANTS: vecuronium • RENAL FAILURE: anaesthesia






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Copyright © 1984 by the Canadian Anesthesiologists' Society.