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Canadian Journal of Anesthesia, Vol 31, 599-603, Copyright © 1984 by Canadian Anesthesiologists' Society

Intramuscular Cimetidine and Ranitidine as Prophylaxis Against Gastric Aspiration Syndrome - A Randomized Doubleblind Study

PAUL W. HARRIS MD1, DAVID H. MORISON MB CHB1, GEOFFREY L. DUNN MB BS1, ANGELICA M. FARGAS-BABJAK MD1, GIRISH C. MOUDGIL MB BS1, KARI G. SMEDSTAD MB CHB1, and JOSEPH WOO MB CHB1

1 Department of Anaesthesia, McMaster University, Hamilton, Ontario

Address correspondence to: Dr. D.H. Morison, Department of Anaesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5.

Preoperative cimetidine 300 mg or ranitidine in 50 and 100 mg doses were administered intramuscularly to 120 patients in a randomized double-blind study. The volume and pH of gastric aspirate samples obtained after tracheal intubation and before extubation were measured. The pH of gastric aspirate was higher following ranitidine 100 mg than ranitidine 50 mg or cimetidine 300 mg at both intubation and extubation (p = 0.006). In addition, fewer patients tended to be "at risk" of pulmonary aspiration syndrome (pH ≤ 2.5) after ranitidine 100 mg than ranitidine 50 mg or cimetidine 300 mg.

Preoperative intramuscular ranitidine 100 mg was found to be suitable for use in protection against gastricaspiration syndrome.

Key Words: HISTAMINE: cimetidine, ranitidine • COMPLICATIONS: aspiration prophylaxis






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Copyright © 1984 by the Canadian Anesthesiologists' Society.