CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SAFWAT, A. M.
Right arrow Articles by BILTON, D. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SAFWAT, A. M.
Right arrow Articles by BILTON, D. C.

Canadian Journal of Anesthesia, Vol 31, 638-641, Copyright © 1984 by Canadian Anesthesiologists' Society

The Use of Propranolol in Rapid Sequence Anaesthetic Induction: Optimal Time Interval for Pretreatment

AMIRA M. SAFWAT MD1, DENNIS L. FUNG MD1, and DONNA C. BILTON MD1

1 Department of Anaesthesiology, University of California, School of Medicine, Sacramento, California

Address correspondence to: Dr. Amira M. Safwat, University of California, Davis Medical Center, Department of Anesthesiology, 2315 Stockton Boulevard, Sacramento, California 95817.

Forty patients ASA physical status I-III were selected and divided into four groups. Group I, Control, received saline pretreatment five minutes prior to rapid sequence induction and intubation, while Groups II, III and IV receivedpropranolol 0.01 mg·kg-1 IV two, five or eight minutes prior to induction and intubation. Measurements of heart rate (HR), arterial blood pressure (ABP) were recorded as baseline values and at one, two, five, eight and 20 minutes, and simultaneous venous samples were withdrawn for propranolol levels. Calculated rate pressure product (RPP) showed best haemodynamic control in Group III. Serum propranolol levels were under 5 ng·ml-1 in Group III and undetectable in Group IV. Our data show that the optimal time interval between IV propranolol administration and intubation was five minutes.

Key Words: SYMPATHETIC NERVOUS SYSTEM, SYMPATHOLYTIC AGENTS: propranolol • ANAESTHETIC TECHNIQUES: rapid sequence induction • COMPLICATIONS: hypertension, tachycardia






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 by the Canadian Anesthesiologists' Society.