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Canadian Journal of Anesthesia, Vol 31, 642-645, Copyright © 1984 by Canadian Anesthesiologists' Society

Lack of Tolerance to Cyclopropane and Cross-Tolerance to Halothane in Rats

EDWIN S. MUNSON MD1

1 Department of Anesthesiology, University of Florida College of Medicine, and the Anesthesiology Service, Veterans Administration Medical Center, Gainesville, Florida

Address correspondence to: Dr. Edwin S. Munson, Department of Anesthesiology, University of Kentucky Medical Center, Lexington, Kentucky, 40536.

Cyclopropane requirement (MAC) in rats was determined before, during, and after repeated exposure to anaesthetic concentrations of cyclopropane and halothane for one hour every day for 20 and 30 days, respectively. MAC values during and after exposure ranged from 93 to 103 per cent (mean = 99 per cent) of control values, which indicates a lack of significant tolerance to cyclopropane or a cross-tolerance between cyclopropane and halothane.

Key Words: ANAESTHETICS, GASES: cyclopropane, halothane • INTERACTIONS: cross-tolerance, tolerance • PHARMACOKINETICS • tolerance • POTENCY, ANAESTHETIC: minimum alveolar concentration • TOLERANCE






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Copyright © 1984 by the Canadian Anesthesiologists' Society.