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Canadian Journal of Anesthesia, Vol 31, 646-649, Copyright © 1984 by Canadian Anesthesiologists' Society

Oral Flunitrazepam in the Prevention of Local Anaesthetic-Induced Convulsions in Mice

E. VATASHSKY MD1, B. BEILIN MD1, H. B. ARONSON MB CHB, FFARCS(I)1, and M. WEINSTOCK MSC PHD1

1 Department of Anaesthetics, Hadassah University Hospital, Mount Scopus and Department of Pharmacology, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Address correspondence to: Dr. E. Vatashsky, Department of Anaesthetics, Hadassah University Hospital, Mount Scopus, POB 24035, Jerusalem 91240, Israel.

The present study determined whether oral flunitrazepam was effective reducing CNS toxicity of lidocaine and bupivacaine. Pretreatment of mice with flunitrazepam, 0.065-0.25 mg·kg-1, significantly reduced or prevented convulsions and mortality induced by lidocaine 106 and 209 mg·kg-1 or bupivacaine 58 and 90 mg·kg-1 injected intraperitonally. The doses of flunitrazepam used did not cause measurable sedation in mice. The efficacy of oral flunitrazepam in preventing local anaesthetic-induced convulsions is similar to that previously reported by intraperitoneal or intramuscular injections in mice.

Flunitrazepam could be useful for oral premedication of patients before regional anaesthesia.

Key Words: HYPNOTICS, BENZODIAZEPINES: flunitrazepam • ANAESTHETICS, local: lidocaine, bupivacaine • COMPLICATIONS: local anaesthetic toxicity, convulsions






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Copyright © 1984 by the Canadian Anesthesiologists' Society.