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Canadian Journal of Anesthesia, Vol 31, 650-653, Copyright © 1984 by Canadian Anesthesiologists' Society

Common Bile Duct Pressure in Dogs after Opiate Injection - Epidural Versus Intravenous Route

ELIK VATASHSKY MD1, YUVAL HASKEL MD1, BENZION BEILIN MD1, and H. B. ARONSON MB CHB DA FFARCS(I)1

1 Departments of Anaesthetics and General Surgery, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel

Address correspondence to: Dr. E. Vatashsky, Department of Anaesthetics Hadassah University Hospital, Mount Scopus POB 24035, Jerusalem 91240, Israel.

The effect on the common bile duct pressure of epidurally injected morphine andfentanyl, was compared with that of intravenous injections of the same drugs in 12 mongrel dogs. Intravenous injection of morphine (0.1 mg·kg-1) or fentanyl (0.01 mg·kg-1) significantly elevated the common bile duct pressure from 10.48 ± 0.37 to 21.68 ± 0.33 cm H2O and from 9.66 ± 0.33 to 14.14 ± 0.21 cm H2O respectively. These increases occurred within 4-15 minutes after injection and lasted for about 2-3 hours. When the narcotics in identical dosages were injected epidurally, the common bile duct pressures were unchanged during the four hours of investigation.

Further studies are planned to determine whether this beneficial effect of epidural narcotics applies also in the human clinical situation.

Key Words: ANALGESICS: morphine, fentanyl • ANALGESIA POSTOPERATIVE: epidural • COMMON BILE DUCT • pressure






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Copyright © 1984 by the Canadian Anesthesiologists' Society.