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Canadian Journal of Anesthesia, Vol 32, 1-4, Copyright © 1985 by Canadian Anesthesiologists' Society

Accelerated Onset of Pancuronium with Divided Doses

WILLIAM G. DOHERTY MB FFARCSI1, PATRICK J. BREEN MB FFARCSI1, FRANCOIS DONATI MD PHD1, and DAVID R. BEVAN MB MRCP FFARCS1

1 Departments of Anaesthesia, Royal Victoria Hospital & McGill University, Montreal, Quebec

Address correspondence to: Dr. D.R. Bevan, Department of Anaesthesia, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, H3A 1A1.

To determine the consequences of administering neuromuscular relaxants in divided doses, pancuronium was given either in a single dose, 0.07 mg·kg-1, or in an initial dose of 0.007 mg·kg-1 followed three minutes later with 0.063 mg·kg-1. When the drug was administered in divided dosage the onset time was reduced, the block was more intense and its duration of action was prolonged. It is suggested that such changes may be advantageous in the provision of rapid intense paralysis.

Key Words: NEUROMUSCULAR RELAXANTS: pancuronium • NEUROMUSCULAR BLOCKADE: onset






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Copyright © 1985 by the Canadian Anesthesiologists' Society.