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Canadian Journal of Anesthesia, Vol 32, 23-29, Copyright © 1985 by Canadian Anesthesiologists' Society

Spinal Cord Blood Flow Following Sub-Arachnoid Tetracaine

RAYMOND KOZODY MD FRCP(C)1, RICHARD J. PALAHNIUK MD FRCP(C)1, and MAUREEN O. CUMMING RN BSC1

1 Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba

Address correspondence to: Dr. Raymond Kozody, Department of Anaesthesia, Health Sciences Centre, 700 William Avenue, Winnipeg, Manitoba, Canada R3E 0Z3.

Spinal cord and spinal dural blood flow in the cervical, thoracic and lumbosacral regions were measured in dogs using the radioactive microsphere technique. Measurements were taken before and 20 and 40 minutes after lumbar subarachnoid injection of one of the following: (1) physiologic saline; (2) tetracaine 20 mg or (3) tetracaine 20 mg with epinephrine 200 µg. No significant change in spinal cord or spinal dural blood flow occurred following subarachnoid physiologic saline or tetracaine with epinephrine. Dogs receiving subarachnoid tetracaine demonstrated a significant increase in lumbosacral spinal cord, and thoracic and lumbosacral dural blood flow at 20 and 40 minutes following injection. Cervical dural blood flow was significantly increased at 40 minutes after subarachnoid tetracaine. Lumbar subarachnoid tetracaine (20 mg) produces a regional spinal cord and generalized dural hyperemia which is prevented by the addition of epinephrine (200 µg).

Key Words: ANAESTHETIC TECHNIQUES: subarachnoid block • ANAESTHETICS, LOCAL: tetracaine • SYMPATHETIC NERVOUS SYSTEM, CATECHOLAMINES: epinephrine • SPINAL CORD: blood flow






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Copyright © 1985 by the Canadian Anesthesiologists' Society.