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Canadian Journal of Anesthesia, Vol 32, 53-55, Copyright © 1985 by Canadian Anesthesiologists' Society

Hepatitis due to Repeated Inhalation of Methoxyflurane in Subanaesthetic Concentrations

TADAO OKUNO MD1, MAKOTO TAKEDA MD1, MASAHIDE HORISHI MD1, TAKESHI OKANOUE MD1, and TATSURO TAKINO MD1

1 Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

Address correspondence to: Dr. Tadao Okuno, Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Dori, Hirokoji-Agaru, Kamigyo-Ku, Kyoto, 602, Japan.

The authors present a case of hepatitis, which was due to repeated self-administered inhalation of methoxyflurane in subanaesthetic concentrations for insomnia. The diagnosis of viral hepatitis, type A or type B, was excluded on the basis of serologic findings. This case is of particular interest in that methoxyflurane even in subanaesthetic concentrations caused hepatic damage on repeated exposure.

Key Words: ANAESTHETICS: methoxyflurane, abuse • LIVER: hepatitis






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Copyright © 1985 by the Canadian Anesthesiologists' Society.