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Canadian Journal of Anesthesia, Vol 32, 178-181, Copyright © 1985 by Canadian Anesthesiologists' Society

Anaphylactoid Reactions to Vancomycin during Anaesthesia: Two Clinical Reports

NIGEL L. P. SYMONS MBBS FFARACS1, ALICK F. T. HOBBES MBBS BSCMED FFARACS1, and HAL K. LEAVER MBBS1

1 Department of Anaesthesia, Royal North Shore Hospital of Sydney, St. Leonards, N.S.W., Australia

Address correspondence to: Dr. N.L.P. Symons, Department of Anaesthesia, The Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4.

Vancomycin is becoming increasingly used for prophylaxis, and treatment against resistant forms of penicillinase-producing staphylococci. This drug, and the aminoglycosides as a group, have serious side-effects and organ toxicity, and may interact with anaesthetic drugs, particularly muscle relaxants. Two cases of anaphylactoid reactions to vancomycin are reported. The first patient subsequently developed oliguria and marked oedema, while the second developed non-cardiogenic pulmonary oedema.

Key Words: ANAESTHESIA: vascular • COMPLICATIONS: anaphylactoid reactions, pulmonary oedema • ANTIBIOTICS: vancomycin






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Copyright © 1985 by the Canadian Anesthesiologists' Society.