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Canadian Journal of Anesthesia, Vol 32, 268-271, Copyright © 1985 by Canadian Anesthesiologists' Society

Clinical Reports: Malignant Hyperthermia: A Possible New Variant

DON S. LEE MD1, JOHN P. ADAMS MD1, and JACK E. ZIMMERMAN MD1

1 Departments of Anaesthesiology and Orthopedic Surgery, The George Washington University Medical Center, Washington, D.C.

Address correspondence to: Dr. Don S. Lee, Department of Anesthesiology, George Washington University Medical Center, 901 Twenty-third Street, N.W., Washington, D.C. 20037.

A young healthy male, who had three consecutive episodes of postoperative hyperthermia was anaesthetized with special precautions to prevent malignant hyperthermia. Despite neuroleptic anaesthesia and dantrolene pretreatment, the patient experienced post-anaesthetic hyperthemia. The patient's clinical picture was almost identical to the symptoms experienced by two of his maternal relatives. All three experienced nausea, vomiting, muscle cramps and high fever which occurred between five to seven hours after general anaesthesia. The serum potassium (K) and creatinine phosphokinase (CPK) levels determined during the hyperthermic episode and on the next day were not elevated. On the basis of the patient's family history, his clinical picture, and his laboratory data, we speculate that this patient might have a form of malignant hyperthermia or a possible new variant.

Key Words: HYPERTHERMIA: malignant, postoperative • GENETIC FACTORS: hyperthermia






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Copyright © 1985 by the Canadian Anesthesiologists' Society.