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Canadian Journal of Anesthesia, Vol 32, 358-363, Copyright © 1985 by Canadian Anesthesiologists' Society

Plasma Levels of Vitamin E and Lipoperoxide during Paediatric Anaesthesia

H. OBARA MD1, N. MAEKAWA MD1, H. HOSHINA MD1, O. TANAKA MD1, R. CHUMA MD1, S. IWAI MD1, H. HISANO MD1, K. NAKAMURA MD1, and T. YAMAMOTO MD1

1 Departments of Anaesthesia and Pediatric Surgery, Kobe University School of Medicine, Kobe, Japan and Department of Pediatric Surgery, Takatsuki Hospital, Takatsuki City, Osaka, Japan

Address correspondence to: Dr. Hidefumi Obara, Department of Anaesthesia, Kobe University School of Medicine, Kusunoki-cho 7, Chuo-ku, Kobe, Japan 650.

We measured plasma levels of vitamin E (total tocopherol) and lipoperoxide in seventeen neonates (<10 days), twenty infants (1-12 months) and ten children (1-5 years) during anaesthesia.

The seventeen neonates were randomly divided into two groups; seven who received 30 mg·kg-1 of {alpha}-tocopheryl acetate intramuscularly before anaesthesia and ten who did not. The 20 infants were divided into three groups: Group 1: eight infants who did not receive vitamin E; Group 2: six who received 30 mg·kg-1 of {alpha}-tocopheryl acetate orally for three days before anaesthesia; Group 3: six who received 30 mg·kg-1 of {alpha}-tocopheryl acetate intramuscularly three hours before anaesthesia.

In the neonates who did not receive {alpha}-tocopheryl acetate, plasma vitamin E and lipoperoxide levels were unchanged following surgery. In Group 1 infants, plasma vitamin E levels decreased (p < 0.05) and plasma lipoperoxide levels increased (p < 0.05).

In both neonates who received vitamin E and Group 3 infants the mean plasma vitamin E levels increased significantly (p < 0.05) following surgery. In Group 2 infants, the levels of plasma vitamin E before surgery were high, as compared to the other groups: however, plasma vitamin E levels decreased following surgery.

In the children, the plasma vitamin E levels were unchanged, while the plasma lipoperoxide levels decreased significantly (p < 0.05) during anaesthesia.

It is suggested from our studies that plasma vitamin E levels decrease and plasma lipoperoxide levels increase during anaesthesia and surgery in infants; however, those levels are unchanged in neonates.

Key Words: ANAESTHESIA: paediatric • METABOLISM: vitamin E, lipoperoxide






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Copyright © 1985 by the Canadian Anesthesiologists' Society.