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Canadian Journal of Anesthesia, Vol 32, 472-478, Copyright © 1985 by Canadian Anesthesiologists' Society

Spinal Cord Blood Flow Following Sub-Arachnoid Lidocaine

RAYMOND KOZODY MD FRCPC1, JO SWARTZ MD FRCPC1, RICHARD J. PALAHNIUK MD FRCPC1, DIANE R. BIEHL MD FRCPC1, and JOHN G. WADE MD FRCP1

1 Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba

Address correspondence to: Dr. R. Kozody, Department of Anaesthesia, Health Sciences Centre, LB315-60 Pearl Street, Winnipeg, Manitoba, Canada R3E 0Z3.

Twelve mongrel dogs were randomized into two equal groups. Cervical, thoracic and lumbosacral spinal cord and spinal dural blood flows were measured using the radioactive microsphere technique. Blood flow determinations were made prior to and 20 and 40 minutes following lumbar subarachnoid injection of: (1) two per cent lidocaine (100 mg) or (2) two per cent lidocaine (100 mg) with 1/25,000 epinephrine (200 µg). Dogs receiving subarachnoid lidocaine demonstrated a decrease in mean arterial blood pressure of 23 per cent and 14 per cent (p < 0.05), while dogs receiving lidocaine with epinephrine had a decrease of 38 and 34 per cent (p < 0.05) at 20 and 40 minutes respectively. Cardiac index was not significantly changed in either group. Lumbar subarachnoid lidocaine (100 mg) produced a rapid regional dural hyperemia (observed at 20 minutes postinjection) and a delayed regional spinal cord hyperemia (observed at 40 minutes postinjection) which were not observed following the addition of epinephrine (200 µg).

Key Words: ANAESTHETIC TECHNIQUES: subarachnoid block • ANAESTHETICS, LOCAL: lidocaine • SYMPATHETIC NERVOUS SYSTEM, CATECHOLAMINES: epinephrine • SPINAL CORD: blood flow






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Copyright © 1985 by the Canadian Anesthesiologists' Society.