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Canadian Journal of Anesthesia, Vol 32, 646-650, Copyright © 1985 by Canadian Anesthesiologists' Society

Baroreflex Function in a Patient with Bartter's Syndrome

TOSHIAKI NISHIKAWA MD1 and SHUJI DOHI MD1

1 Department of Anesthesiology, Sapporo Medical College and Hospital, Chuoku, Sapporo, Hokkaido and the Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Sakuramura, Ibaraki, Japan

Address correspondence to: Dr. Nishikawa, Department of Anesthesiology, Sapporo Medical College and Hospital, South-1, West-16, Chuoku, Sapporo, Hokkaido 060 Japan.

There is little information regarding circulatory responses in Bartter's syndrome, with the exception of marked resistance to vasopressors. We investigated baroreflex function in a 40-year-old woman with this syndrome. The patient showed oscillation of heart rate even with a small increase in blood pressure after administration of vasopressor agents. Variations in heart rate and blood pressure were exaggerated during halothane, nitrous oxide and oxygen anaesthesia. Although the mechanism of the unstable baroreflex in this syndrome remains to be proved, the instability may be attributable to many factors such as prostaglandins, hypovolemia, hypokalemia, halothane, nitrous oxide and positive pressure ventilation.

Key Words: COMPLICATIONS: Bartter's syndrome • HORMONE: prostaglandins • REFLEX: baroreflex • SYMPATHETIC NERVOUS SYSTEM: sympathomimetic agents






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Copyright © 1985 by the Canadian Anesthesiologists' Society.