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Canadian Journal of Anesthesia, Vol 33, 162-166, Copyright © 1986 by Canadian Anesthesiologists' Society

Pharmacokinetics of Meperidine in Spinal Anaesthesia

MOHAMED NAGUIB MB B CH MSC FFARCSI, C. E. FAMEWO MB FRCPC, and AFAF ABSOOD BS MS1

1 Departments of Anesthesiology and Clinical Pharmacology, King Faisal University, Saudi Arabia

Address correspondence to: Dr. M. Naguib, Department of Anesthesiology, King Faisal University, King Fahd Hospital, P.O. Box 2208, Al-Khobar, Saudi Arabia 31952.

Five male patients undergoing haemorrhoidectomy received intrathecal meperidine 1 mg·kg-1. as the sole anaesthetic agent. Plasma concentration-time profiles were investigated. The peak plasma concentration of meperidine was 175 ± 78.8 ng·ml-1. (mean ±SD) and this occurred 90 minutes after intrathecal injection. The plasma concentrations generally were lower than those necessary for systemic analgesic effects. The terminal elimination half life of meperidine (t1/2 ({beta}) in the plasma was 198 minutes.

Intrathecal meperidine produced good surgical anaesthesia in all patients studied. The mean duration of sensory and motor block was 77 ± 18.8 and 47 ± 7.4 minutes respectively. Four patients did not require any analgesic supplement during the postoperative period. No patient developed clinically evident respiratory depression or neurological sequlae.

The pharmacokinetic data suggests that intrathecal meperidine provides prolonged postoperative analgesia through a regional effect on opioid receptors in the spinal cord

Key Words: ANAESTHETIC TECHNIQUES: spinal anaesthesia • ANAESTHETIC: local, meperidine • PHARMACOKINETICS: kinetics • PAIN: postoperative






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Copyright © 1986 by the Canadian Anesthesiologists' Society.