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Canadian Journal of Anesthesia, Vol 33, 287-293, Copyright © 1986 by Canadian Anesthesiologists' Society

The Comparative Efficacy of Cimetidine and Ranitidine in Controlling Gastric Ph in Critically ill Patients

STEWART ROSS REID MD1 and CHARLES DUGALD BAYLIFF PHARM D1

1 Departments of Anaesthesia and Pharmacy, University of Toronto, Sunnybrook Medical Centre, Toronto, Ontario

Address correspondence to: Dr. S. R. Reid, Department of Anaesthesia, Sunnybrook Medical Centre, 2075 Bay view Avenue, Toronto, Ontario, Canada, M4N 3M5.

The comparative efficacy of intravenous cimetidine and ranitidine in controlling gastric pH in 100 intensive care unit patients was assessed in a double blind, prospective, randomized study. The total number of gastric pH determinations and the number ofpH determinations with pH less than five were recorded. Patients received either cimetidine or ranitidine via continuous infusion, with dosage adjustments for patients with renal insufficiency. Antacids were administered each time the gastric pH was less than five. There was no difference overall in the number of patients who had at least one gastric pH determination < pH 5. There was however, a larger proportion of patients with ≥10,≥15, ≥20 and ≥25 per cent of gastric pH determination < pH5 in the cimetidine group than in the ranitidine group. This difference was statistically significant for ≥25 per cent. The drugs were well tolerated. Ranitidine was as effective as cimetidine and possibly more so in controlling gastric pH.

Key Words: GASTROINTESTINAL TRACT: gastric pH, cimetidine, ranitidine • HISTAMINE-2 RECEPTOR ANTAGONISTS: cimetidine, ranitidine






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Copyright © 1986 by the Canadian Anesthesiologists' Society.