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Canadian Journal of Anesthesia, Vol 33, 785-789, Copyright © 1986 by Canadian Anesthesiologists' Society

Clinical Reports: Recognition of an Unsuspected Phaeochromocytoma During Elective Coronary Artery Bypass Surgery

PHILIP BROWN MB BS FRCPC FFA RACS1 and ROBERT A. CAPLAN MD1

1 Department of Anesthesiology RN-10, University of Washington School of Medicine, Seattle, Washington 98195

Address correspondence to: Dr. Caplan.

A patient with a longstanding history of mild hypertension undergoing elective coronary artery bypass grafting exhibited extreme and paroxysmal elevations of systemic blood pressure immediately after separation from cardiopulmonary bypass. Conventional antihypertensive therapy (nitroprusside, hydralazine, propranolol) was ineffective, whereas phentolamine infusion produced a decrease in systemic blood pressure. These observations led to the discovery of a predominantly norepinephrine-secreting phaeochromocytoma. This case is noteworthy in that cardiopulmonary bypass may have served as a stimulus for tumour secretion of catecholamine. Possible mechanisms for this effect are discussed.

Key Words: SURGERY: phaeochromocytoma, cardiovascular, cardiopulmonary bypass • ANAESTHETIC, INTRAVENOUS: fentanyl







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Copyright © 1986 by the Canadian Anesthesiologists' Society.