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Canadian Journal of Anesthesia, Vol 34, 437-441, Copyright © 1987 by Canadian Anesthesiologists' Society

ARTICLES

Arterial PaO2 and PaCO2 influence seizure duration in dogs receiving electroconvulsive therapy

CD Crawford, P Butler and A Froese
Department of Anaesthesia, Queen's University, Kingston, Ontario.

The influence of arterial O2 and CO2 tensions on electroconvulsive seizure duration was investigated in five mongrel dogs under consistent anaesthetic conditions. Seizure durations were measured in a randomized protocol of nine possible combinations of arterial gas tension spanning increased, normal or decreased levels of PaO2 and PaCO2. Seizure duration was directly related to PaO2 (p less than 0.00001) and inversely related to PaCO2 (p less than 0.0001). A significant synergism was evident at the extremes of PaO2 and PaCO2, with seizure duration being greater than predicted for hyperoxia-hypocapnia and hypoxia-hypercapnia and shorter than predicted for hypoxia-hypocapnia and hyperoxia-hypercapnia. We conclude that arterial gas tensions strongly influence ECT-induced seizure duration and through this may influence the therapeutic efficacy of electroconvulsive therapy.


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 Canadian J. AnesthesiaHome page
A. Mohanram, V. Kumar, Z. Iqbal, S. Markan, and P. S. Pagel
Repetitive generalized seizure-like activity during emergence from sevoflurane anesthesia: [Activite semblable a une crise convulsive repetitive generalisee pendant l'emergence de l'anesthesie au sevoflurane]
Can J Anesth, August 1, 2007; 54(8): 657 - 661.
[Abstract] [Full Text] [PDF]


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Copyright © 1987 by the Canadian Anesthesiologists' Society.