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Canadian Journal of Anesthesia, Vol 35, 413-416, Copyright © 1988 by Canadian Anesthesiologists' Society

ARTICLES

Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome

WC Parris, JA Oates, J Kambam, R Shmerling and JF Sawyers
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232.

Carcinoid syndrome produces flushing, bronchoconstriction and gastrointestinal hypermotility secondary to serotonin, histamine, bradykinin and prostaglandin release. A variety of drugs, foods and anaesthetic agents may provoke this syndrome. Under anaesthesia, the flushing produced may be associated with acute hypotension and cardiovascular collapse; this phenomenon is called a carcinoid crisis. Recently, somatostatin analogue has been used successfully to treat intraoperative carcinoid crisis. In this report, we present a 66-year-old lady with carcinoid syndrome who was pre-treated with 50 micrograms somatostatin analogue IV and IM prior to surgical manipulation. The anaesthetic course was relatively uneventful and the patient did well postoperatively.


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Copyright © 1988 by the Canadian Anesthesiologists' Society.