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Canadian Journal of Anesthesia, Vol 37, 341-347, Copyright © 1990 by Canadian Anesthesiologists' Society

ARTICLES

Perioperative management of patients with von Willebrand's disease

CB Cameron and N Kobrinsky
Department of Anaesthesia, University of Manitoba, Children's Hospital, Winnipeg, Canada.

This review focuses on the pathophysiology of the Factor VIII molecule as it relates to Von Willebrand's disease. Three major categories of Von Willebrand's disease are identified. The perioperative diagnosis and management of all categories are reviewed. 1-Deamino-8-D-arginine vasopressin (DDAVP) is presented as an alternative to the transfusion of blood and blood products for the management of a bleeding diathesis.




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Copyright © 1990 by the Canadian Anesthesiologists' Society.