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Canadian Journal of Anesthesia, Vol 37, 556-559, Copyright © 1990 by Canadian Anesthesiologists' Society

ARTICLES

Diltiazem and nifedipine reduce the in vitro contracture response to halothane in malignant hyperthermia-susceptible muscle

PJ Adnet, RM Krivosic-Horber, G Haudecoeur, HG Reyford, MM Adamantidis and BA Dupuis
Department of Anesthesiology, University of Lille, France.

The effects of diltiazem (1 microM) and nifedipine (1 microM) were examined separately on the in vitro halothane tests for malignant hyperthermia (MH) susceptibility. Eighteen patients with MH susceptibility were diagnosed as MH-susceptible (MHS) according to the protocol of the European MH Group. In addition, halothane tests were carried out in the presence of either diltiazem (ten patients) or nifedipine (eight patients). These two calcium channel blockers significantly reduced the halothane contracture. Furthermore, in five of the ten MHS patients tested in the presence of diltiazem as well as in five of the eight MHS patients tested in the presence of nifedipine the halothane contracture test could be classified as negative. It is concluded that the presence of clinical concentrations of either diltiazem or nifedipine in the muscle bath affects the in vitro discrimination for MH susceptibility to halothane.




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Copyright © 1990 by the Canadian Anesthesiologists' Society.