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Canadian Journal of Anesthesia, Vol 38, 401-407, Copyright © 1991 by Canadian Anesthesiologists' Society

ARTICLES

Relationships between block-of-twitch and train-of-four fade in the mouse phrenic nerve-diaphragm preparation

RJ Storella, SA Slomowitz and H Rosenberg
Department of Anesthesiology, Hahnemann University, Philadelphia, PA 19102.

The relationships between the block-of-twitch and train-of-four fade in the presence of nondepolarizing neuromuscular blocking drugs (d-tubocurarine, vecuronium and pancuronium) were examined in vitro by measuring the contractile tension from mouse phrenic nerve-diaphragm preparations. The slope of the block/fade relationship differed between onset of and recovery from neuromuscular block following single doses of d-tubocurarine, vecuronium or pancuronium. Decreasing the dose of d-tubocurarine or using a divided dose technique to accelerate onset (i.e., priming) increased the amount of fade for a given amount of block. In addition, the block/fade relationships for cumulative dosing and sequential dilution were the same when measurements were made at steady-state for several doses. It is concluded that the block/fade relationship in the mouse phrenic nerve-diaphragm preparation is variable, and is related to the time course of the neuromuscular block. In addition, the block/fade relationships for d-tubocurarine, vecuronium and pancuronium did not differ when determined at steady-state.


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H. Itoh, K. Shibata, S. Nitta, and T. Kobayashi
Train-of-four fade and neuromuscular block in rats: a comparison between pancuronium, vecuronium, and rocuronium
Can J Anesth, October 1, 2000; 47(10): 950 - 955.
[Abstract] [PDF]


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Copyright © 1991 by the Canadian Anesthesiologists' Society.