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Canadian Journal of Anesthesia, Vol 38, 974-979, Copyright © 1991 by Canadian Anesthesiologists' Society

ARTICLES

Transcranial Doppler sonography: nitrous oxide and cerebral blood flow velocity in children

JE Leon and B Bissonnette
Department of Anaesthesia, Hospital for Sick Children, University of Toronto, Ontario, Canada.

To determine the effect of nitrous oxide (N2O) on cerebral blood flow velocity (CBFV) and cerebrovascular resistance index (RI+) in children, ten ASA physical status I or II patients aged one to eight years old, scheduled for urological procedures, were studied. Anaesthesia was induced with thiopentone 2 mg.kg-1, fentanyl 5 micrograms.kg-1 and diazepam 0.3 mg.kg-1. Muscular relaxation was ensured by using vecuronium 0.1 mg.kg-1. After tracheal intubation, anaesthesia was randomly assigned to either a mixture of air in oxygen (N2/O2) or 70% N2O in oxygen (N2O/O2) producing an FIO2 of 30%. Three sets of measurements of CBFV and RI+ were made with both gas mixtures. The CBFV and RI+ were measured in the middle cerebral artery (MCA) with a transcranial Doppler monitor. Measurements were made while using the initial gas mixture, then the second gas mixture was administered, and finally, the patient again was given the initial gas mixture. A continuous caudal epidural or lumbar epidural block was performed before skin incision. Neuromuscular blockade was maintained with vecuronium 0.05 mg.kg-1. Temperature, heart rate, end-tidal CO2, arterial oxygen saturation, haematocrit and arterial blood pressure were maintained constant. Ventilation was adjusted to achieve normocapnia. The CBFV increased when 70% N2/O2 was replaced by 70% N2O/O2 (P less than 0.05) while the CBFV decreased when 70% N2/O2 was readministered (P less than 0.05). Likewise, the CBFV decreased when 70% N2O/O2 was replaced by 70% N2/O2 (P less than 0.05) while the CBFV increased when 70% N2O/O2 was readministered (P less than 0.05).


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C. Karsli, E. Wilson-Smith, I. Luginbuehl, and B. Bissonnette
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Copyright © 1991 by the Canadian Anesthesiologists' Society.