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Canadian Journal of Anesthesia, Vol 39, 170-172, Copyright © 1992 by Canadian Anesthesiologists' Society

ARTICLES

Use of propofol for the prevention of chemotherapy-induced nausea and emesis in oncology patients

CS Scher, D Amar, RH McDowall and SM Barst
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.

Nausea and vomiting associated with antineoplastic chemotherapy are distressing and may keep patients from complying with chemotherapy protocols. No drug has emerged among many as an effective antiemetic. It has been speculated that propofol may have intrinsic antiemetic properties. We report the use of low-dose continuous infusion propofol in three oncology patients to treat chemotherapy-associated nausea and vomiting. A bolus of 0.1 mg.kg-1 followed by a continuous infusion of 1 mg.kg-1.hr-1 was effective in both prevention and treatment of nausea and vomiting. All three patients were alert, reported low nausea scores by visual analogue scale, and had no episodes of vomiting. When the infusion was discontinued, nausea and vomiting were noted in two patients. Propofol, given in a subanaesthetic infusion, was safe and effective as an antiemetic in these three patients.


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S. Tomioka, T. Kurio, K. Takaishi, and N. Nakajo
Propofol Is Effective in Chemotherapy-Induced Nausea and Vomiting: A Case Report with Quantitative Analysis
Anesth. Analg., September 1, 1999; 89(3): 798 - 798.
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Copyright © 1992 by the Canadian Anesthesiologists' Society.