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Canadian Journal of Anesthesia, Vol 39, 911-914, Copyright © 1992 by Canadian Anesthesiologists' Society


ARTICLES

Epidural morphine reduces halothane MAC in humans

IM Schwieger, CE Klopfenstein and A Forster
Departement D'Anesthesiologie, Hopital Cantonal Universitaire, Geneve, Suisse.

The effect of epidural morphine sulphate (4 mg in 10 ml saline) on the minimum alveolar concentration of halothane was investigated in a double-blind, randomized fashion in ten adult patients undergoing abdominal surgery, and compared with the minimum alveolar concentration of halothane after epidural administration of 10 ml saline in a similar group of patients. Morphine sulphate, administered through the epidural catheter 98 +/- 33 min before to skin incision reduced the minimum alveolar concentration of halothane by 28% (0.57% vs 0.78%, P < 0.05).





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Copyright © 1992 by the Canadian Anesthesiologists' Society.