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Canadian Journal of Anesthesia, Vol 4, 265-281, Copyright © 1957 by Canadian Anesthesiologists' Society

The Use of Fluothane in Anaesthesia for Neurosurgery: A Preliminary Report

G. FRED BRINDLE B.A., M.D., C.M.,1, R.G. B. GILBERT F.R.C.P.(C), F.F.A.R.C.S.1, and R. A. MILLAR M.D., F.F.A.R.C.S.1

1 Department of Anaesthesia, Montreal Neurological Institute and McGill University, Montreal, Quebec

The volatile anaesthetic agent, Fluothane, has been employed for 108 neuro-surgical procedures.

The non-irritant, non-explosive properties of Fluothane, together with a desirable flexibility in action, render it a potentially valuable agent for the anaesthetic management of the neurosurgical patient.

A serious disadvantage of Fluothane derives from its hypotensive action, which may appear before an adequate level of anaesthesia has been attained.

There is electrocardiographic evidence that the combination of Fluothane and subcutaneously injected adrenaline is a potential hazard in man.

Tests of liver function after prolonged operations reveal definite abnormality, but this may not be greater than it would be with other anaesthetic agents administered and studied under similar conditions.

Fluothane deserves continued investigation as a promising new agent for major neurosurgical procedures. At the present time, its use can be particularly recommended for neuro-radiological investigations under general anaesthesia.






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Copyright © 1957 by the Canadian Anesthesiologists' Society.