CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DOBKIN, A. B.
Right arrow Articles by WYANT, G. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by DOBKIN, A. B.
Right arrow Articles by WYANT, G. M.

Canadian Journal of Anesthesia, Vol 4, 352-363, Copyright © 1957 by Canadian Anesthesiologists' Society

The Effect of Chlorpromazine on Haemostasis

ALLEN B. DOBKIN M.D.1, LYMAN M. FISHER PH.D.1, and GORDON M. WYANT F.F.A.R.C.S.1

1 Department of Anaesthesia and Physiology, University of Saskatchewan College of Medicine and University Hospital, Saskatoon

A study of the effect of chlorpromazine on the haemostatic mechanism was carried out on thirteen adult male patients in relatively good general health and who were under the stress of preparation for an operation. A reduction in blood pressure indicated a significant decrease in peripheral vascular control, and a decrease in the prothrombin time occurred in most of the patients. These changes did not persist into the postoperative period. Under these clinical conditions and by this technique of study, it was found that chlorpromazine may decrease the coagulability during operation and may increase coagulability postoperatively. The cause of these changes was not revealed.

Note:

This work was supported by the National Research Council of Canada.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1957 by the Canadian Anesthesiologists' Society.