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Canadian Journal of Anesthesia, Vol 4, 372-377, Copyright © 1957 by Canadian Anesthesiologists' Society

Some Effects of Levallorphan on Responses to Meperidine

M. J. SCHIFFRIN PH.D.1, R. C. BALAGOT M.D.2, and MAX S. SADOVE M.D.

1 Department of Clinical Research, Hoffmann-La Roche Inc
2 Division of Anesthesiology, University of Illinois College of Medicine, Chicago, Illinois

Meperidine hydrochloride in doses of 50 and 100 mg. depresses the respiratory response to 5 per cent carbon dioxide in oxygen. This depression may be observed as early as 15 minutes and as late as 90 minutes after subcutaneous or intramuscular injection.

A mixture of meperidine hydrochloride and levallorphan tartrate in a ratio of 100:1 prevents this depression, does not interfere with analgesia, and does not produce more undesirable reactions than does meperidine itself.

Note:

Supplied by Hoffmann La Roche Inc.






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Copyright © 1957 by the Canadian Anesthesiologists' Society.