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Canadian Journal of Anesthesia, Vol 40, 334-339, Copyright © 1993 by Canadian Anesthesiologists' Society

ARTICLES

Histamine release during paediatric cardiopulmonary bypass

DE Withington, WK Man and MJ Elliott
Department of Anaesthesia, St. Thomas' Hospital, London, U.K.

Histamine release is part of the general inflammatory response and occurs during surgery and cardiopulmonary bypass (CPB) in adults. Few data are available for children. Histamine release was studied in 23 children undergoing CPB with standard anaesthetic and CPB techniques. Blood sampling was performed in relation to specific anaesthetic and surgical events, e.g., start of CPB, removal of aortic clamps, reventilation of the lungs. Plasma histamine was determined by a single isotope radioenzymatic technique. There was no consistent histamine release in the study population although there was an increase in plasma histamine concentration in some subjects after initiation of CPB (P < 0.05) and on removal of the aortic cross-clamp (P < 0.05). No correlation was demonstrated between histamine concentration and systolic arterial pressure, temperature, duration of CPB or cross-clamp time. Histamine concentration was positively correlated with heart rate.




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Copyright © 1993 by the Canadian Anesthesiologists' Society.