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Canadian Journal of Anesthesia, Vol 40, 448-452, Copyright © 1993 by Canadian Anesthesiologists' Society

ARTICLES

Cardiovascular stability with rapid intravenous infusion of ondansetron

JS Heyman, ML Young, RJ Bagshaw, WJ Levy, RT Geer, SJ Aukburg, AF Joslyn and TJ Conahan
Department of Anaesthesia, University of Pennsylvania, Philadelphia 19104.

The acute cardiovascular effects of rapid iv administration of the antiemetic ondansetron, a selective serotonin (5-HT3) receptor antagonist were determined in a randomized, blinded, placebo-controlled study. Measurements of heart rate, blood pressure, oxygen saturation and respiratory rate were made preoperatively over a five-minute period which followed a two-minute infusion of the medication. Intraoperative and postoperative data were not collected. None of the variables recorded changed significantly during the infusion or in the observation period which followed. Within the limitations of this study, we detected no cardiovascular change in the five minutes between the end of the drug infusion and the induction of anaesthesia.




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Copyright © 1993 by the Canadian Anesthesiologists' Society.