CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCoy, E. P.
Right arrow Articles by Cooper, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCoy, E. P.
Right arrow Articles by Cooper, R. A.

Canadian Journal of Anesthesia, Vol 40, 703-708, Copyright © 1993 by Canadian Anesthesiologists' Society

ARTICLES

Haemodynamic effects of rocuronium during fentanyl anaesthesia: comparison with vecuronium

EP McCoy, VR Maddineni, P Elliott, RK Mirakhur, IW Carson and RA Cooper
Department of Anaesthesia, Queen's University, Belfast, Northern Ireland.

Haemodynamic variables were measured following administration of rocuronium 0.6 mg.kg-1 or vecuronium 0.08 mg.kg-1 (approximately equivalent to 2 x ED95 doses) in patients anaesthetized with fentanyl 50 micrograms.kg-1 and scheduled to undergo elective coronary artery bypass grafting. There were increases in stroke volume index (+15%) and cardiac index (+11%), and a decrease in pulmonary capillary wedge pressure (-25%) following administration of rocuronium (P < 0.05). The changes in heart rate (+7%), mean arterial pressure (-5%), systemic vascular resistance (-12%) and other measured or derived indices were insignificant. In comparison the administration of vecuronium was associated with decreases in heart rate (-7%), mean pulmonary artery pressure (-17%), central venous pressure (-15%) and the rate-pressure product (-9%) (P < 0.05). The changes in mean arterial pressure (-7%), cardiac index (-6%) and systemic vascular resistance (-8%) following vecuronium were insignificant. There were no differences in any of the variables between rocuronium and vecuronium. The absolute values of all variables were, however, within acceptable clinical limits. There was no evidence of histamine release in any patient. The present study shows that rocuronium 0.6 mg.kg-1 is associated with changes of only small magnitude in haemodynamic variables.


This article has been cited by other articles:


Home page
 Canadian J. AnesthesiaHome page
A. A. Dahaba, E. Schweitzer, R. D. Fitzgerald, and S. Schwarz
Equi-lasting doses of rocuronium, compared to mivacurium, result in improved neuromuscular blockade in patients undergoing gynecological laparoscopy : [Des doses de duree equivalente de rocuronium, compare au mivacurium, ameliorent la curarisation chez des patientes qui subissent une laparoscopie gynecologique]
Can J Anesth, December 1, 2001; 48(11): 1084 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. H. Levy, M. Pitts, A. Thanopoulos, F. Szlam, R. Bastian, and J. Kim
The Effects of Rapacuronium on Histamine Release and Hemodynamics in Adult Patients Undergoing General Anesthesia
Anesth. Analg., August 1, 1999; 89(2): 290 - 290.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
M. R. Belmont and D. L. Reich
Pharmacodynamics of Nondepolarizing Muscle Relaxants
Seminars in Cardiothoracic and Vascular Anesthesia, July 1, 1997; 1(2): 164 - 177.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by the Canadian Anesthesiologists' Society.