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Canadian Journal of Anesthesia, Vol 41, 446-449, Copyright © 1994 by Canadian Anesthesiologists' Society

ARTICLES

Propofol inhibits phagocytosis and killing of Staphylococcus aureus and Escherichia coli by polymorphonuclear leukocytes in vitro

W Krumholz, J Endrass and G Hempelmann
Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University Giessen, Federal Republic of Germany.

Polymorphonuclear leukocytes (PMNL) are important components of the immunological defence system which protects the human organism from invading bacteria. Using a fluorescence microscopic method, we examined the influence of propofol and its solvent intralipid on phagocytosis and killing of Staphylococcus aureus and Escherichia coli by PMNL in vitro. Propofol inhibited (P < or = 0.001) phagocytosis of Staphylococcus aureus as well as Escherichia coli. Killing of Staphylococcus aureus (P < or = 0.001) and of Escherichia coli (P < or = 0.01) was suppressed. Intralipid, by itself, impaired phagocytosis of Escherichia coli (P < or = 0.05). Apart from that, intralipid produced no relevant effects. Additional clinical studies regarding the influence of propofol on PMNL function are recommended.


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T. Nagata, M. Kansha, K. Irita, and S. Takahashi
Propofol inhibits FMLP-stimulated phosphorylation of p42 mitogen-activated protein kinase and chemotaxis in human neutrophils
Br. J. Anaesth., June 1, 2001; 86(6): 853 - 858.
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Copyright © 1994 by the Canadian Anesthesiologists' Society.