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Canadian Journal of Anesthesia, Vol 41, 733-737, Copyright © 1994 by Canadian Anesthesiologists' Society

ARTICLES

Cigarette smoke increases bupivacaine metabolism in rats

B Bruguerolle, L Attolini, X Roucoules and AM Lorec
Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine de Marseille, France.

This study was designed to document possible changes in bupivacaine kinetics in rats after exposure to cigarette smoke. Rats (n = 15) were exposed to cigarette smoke (Borgwaldt type Hamburg II) for ten minutes per day during four days (C) or eight days (B); controls (A) were used simultaneously without exposure to cigarette smoke. After bupivacaine 20 mg.kg-1 ip at day 4 (C) or day 8 (B), blood was sampled (0.5 ml of blood collected by puncture at the retro-orbital sinus 0.25, 0.5, 1, 2, 4, 6 and 8 hours after administration) and bupivacaine and its main metabolite i.e., desbutylbupivacaine (PPX) were determined by gas liquid chromatography. The sensitivity of the method was 15 ng.ml-1 and the reproductibility was < 6%. Serum bupivacaine concentrations were plotted against time and the pharmacokinetic variables were determined assuming a two compartment open model: Cmax, Tmax were derived directly from individual data. The beta phase elimination half-lives (T1/2 beta), the area under the serum concentration curve (AUC0 infinity), the total plasma clearance (Cl) and the total volume of distribution (Vd) were calculated. These variables were assessed according to non-linear fitting method. Cigarette smoking exposure did not change the pharmacokinetic variables of bupivacaine.(ABSTRACT TRUNCATED AT 250 WORDS)




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Copyright © 1994 by the Canadian Anesthesiologists' Society.