CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCoy, E. P.
Right arrow Articles by Paxton, L. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCoy, E. P.
Right arrow Articles by Paxton, L. D.

Canadian Journal of Anesthesia, Vol 42, 213-216, Copyright © 1995 by Canadian Anesthesiologists' Society

ARTICLES

Nondepolarizing neuromuscular blocking drugs and train-of-four fade

EP McCoy, FM Connolly, RK Mirakhur, PB Loan and LD Paxton
Department of Anaesthetics, Queen's University of Belfast, Northern Ireland.

The aim of this study was to examine differences in prejunctional effects of different relaxants by measuring the train-of-four (TOF) fade during the onset and recovery of neuromuscular block. The relaxants studied were atracurium (225 micrograms.kg-1), mivacurium (65 micrograms.kg-1) rocuronium (300 micrograms.kg-1) and vecuronium (40 micrograms.kg-1). The TOF ratios were measured at approximate heights of T1 (first response in the TOF) of 90, 75, 50, and 25%. The TOF fade (as shown by lower TOF ratios) increased with a decrease in the T1 during onset of neuromuscular block. Although there was a slightly greater fade with atracurium and rocuronium during the onset of block, the differences among the relaxants were insignificant. It is concluded that the relative prejunctional effects of these relaxants are similar.


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
G. S. Murphy, J. W. Szokol, J. H. Marymont, M. Franklin, M. J. Avram, and J. S. Vender
Residual Paralysis at the Time of Tracheal Extubation
Anesth. Analg., June 1, 2005; 100(6): 1840 - 1845.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. F. Kopman, N. A. Khan, and G. G. Neuman
Precurarization and Priming: A Theoretical Analysis of Safety and Timing
Anesth. Analg., November 1, 2001; 93(5): 1253 - 1236.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
H. Itoh, K. Shibata, S. Nitta, and T. Kobayashi
Train-of-four fade and neuromuscular block in rats: a comparison between pancuronium, vecuronium, and rocuronium
Can J Anesth, October 1, 2000; 47(10): 950 - 955.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the Canadian Anesthesiologists' Society.