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Canadian Journal of Anesthesia, Vol 43, 1138-1143, Copyright © 1996 by Canadian Anesthesiologists' Society

ARTICLES

Comparison of glucose 7.5% and 0.75% with or without phenylephrine for tetracaine spinal anaesthesia

M Sumi, S Sakura, Y Sakaguchi, Y Saito and Y Kosaka
Department of Anesthesiology, Shimane Medical University, Izumo City, Japan.

PURPOSE: To investigate whether a marginally hyperbaric tetracaine solution with or without phenylephrine could produce consistent blocks as compared with a conventionally hyperbaric tetracaine solution injected at L3-4 interspace with the patient in the lateral position. METHODS: We studied 120 ASA I or II patients scheduled for elective surgery to the lower limb. Patients were randomly divided into four equal groups to receive spinal anaesthesia using tetracaine 0.5% in glucose 0.75% or 7.5%, with or without phenylephrine 0.125%. Neural block was assessed in a double-blind manner by cold, pinprick, and touch sensation, and a modified Bromage scale after the injection of the study drug. RESULTS: The median (10th, 90th percentiles) peak dermatomal level to pinprick obtained by the solutions in glucose 0.75% was T10 (L1, T5), which was lower than that obtained by the solution in glucose 7.5% extending to T5 (T10, T3) and T5 (T10, T2) with or without phenylephrine, respectively (P < 0.0001). The addition of phenylephrine prolonged the time to two-segment regression but did not change the maximum extent of blocks. CONCLUSIONS: A marginally hyperbaric tetracaine with or without phenylephrine produced consistent blocks with spread restricted to the lower thoracic segments when administered intrathecally at the L3-4 interspace with the patient in the lateral position.


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Copyright © 1996 by the Canadian Anesthesiologists' Society.