CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fujii, Y.
Right arrow Articles by Tanaka, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fujii, Y.
Right arrow Articles by Tanaka, H.

Canadian Journal of Anesthesia, Vol 43, 110-114, Copyright © 1996 by Canadian Anesthesiologists' Society

ARTICLES

Antiemetic effects of granisetron on postoperative nausea and vomiting in patients with and without motion sickness

Y Fujii, H Toyooka and H Tanaka
Department of Anaesthesiology and Critical Care Medicine, Tokyo Medical and Dental University School of Medicine, Japan.

PURPOSE: This randomized, placebo-controlled, double-blind study was to evaluate the effects of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, for preventing postoperative nausea and vomiting in 110 patients with (n = 50) and without (n = 60) a history of motion sickness undergoing general anaesthesia for major gynaecological surgery. METHODS: The patients received a single dose of either granisetron (40 micrograms.kg-1) or placebo (saline) iv over 2-5 min immediately before induction of anaesthesia. Postoperatively, during the first 24 hr after anaesthesia, the frequencies of nausea and vomiting were recorded. RESULTS: Except for a positive history of motion sickness, the treatment groups were similar for patient characteristics, types of surgery, anaesthetics administered and opioids given. Postoperatively, the frequency of nausea was 44% and 16% after administration of placebo and granisetron in patients with motion sickness, and was 30% and 7% in patients without it, respectively; the corresponding frequencies of vomiting were 28%, 8%, 13% and 3%. The incidence of adverse events postoperatively were not different among the groups. CONCLUSION: These results suggest that preoperative prophylactic administration of granisetron is effective and safe for preventing postoperative nausea and vomiting in patients with motion sickness as well as in patients without it.


This article has been cited by other articles:


Home page
 The Annals of PharmacotherapyHome page
A. L Kovac
Meta-Analysis of the Use of Rescue Antiemetics Following PONV Prophylactic Failure with 5-HT3 Antagonist/Dexamethasone Versus Single-Agent Therapies
Ann. Pharmacother., May 1, 2006; 40(5): 873 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
Y. Lee, H.-Y. Lai, P.-C. Lin, S.-J. Huang, and Y.-S. Lin
Dexamethasone prevents postoperative nausea and vomiting more effectively in women with motion sickness: [La dexamethasone previent plus efficacement les nausees et les vomissements postoperatoires chez les femmes atteintes du mal des transports]
Can J Anesth, March 1, 2003; 50(3): 232 - 237.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
P. Kranke, C. C. Apfel, N. Roewer, and Y. Fujii
Reported Data on Granisetron and Postoperative Nausea and Vomiting by Fujii et al. Are Incredibly Nice! • Response
Anesth. Analg., April 1, 2000; 90(4): 1004 - 1007.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the Canadian Anesthesiologists' Society.