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Canadian Journal of Anesthesia, Vol 43, 184-191, Copyright © 1996 by Canadian Anesthesiologists' Society

ARTICLES

Study design in clinical research: sample size estimation and power analysis

J Lerman
Department of Anaesthesia, Hospital for Sick Children, Toronto, Ontario, Canada. lerman@sickkids.on.ca

The purpose of this review is to describe the statistical methods available to determine sample size and power analysis in clinical trials. The information was obtained from standard textbooks and personal experience. Equations are provided for the calculations and suggestions are made for the use of power tables. It is concluded that sample size calculations and power analysis can be performed with the information provided and that the validity of clinical investigation would be improved by greater use of such analyses.


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Copyright © 1996 by the Canadian Anesthesiologists' Society.