CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hung, O.
Right arrow Articles by Stanski, D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Hung, O.
Right arrow Articles by Stanski, D.

Canadian Journal of Anesthesia, Vol 43, 450-455, Copyright © 1996 by Canadian Anesthesiologists' Society

ARTICLES

Comparative absorption kinetics of intramuscular midazolam and diazepam

OR Hung, JB Dyck, J Varvel, SL Shafer and DR Stanski
Department of Anaesthesia, Dalhousie University, Halifax, Nova Scotia, Canada. hungorla@ac.dal.ca

PURPOSE: This study investigates the rate and extent of absorption following intramuscular injection of midazolam and diazepam. METHODS: Four healthy male volunteers were recruited in this randomized three-way cross-over study. On one occasion each subject received simultaneous im injections of 5 mg midazolam and 10 mg diazepam in separate deltoid muscles. On two other separate occasions each subject received an iv infusion of 7.5 mg midazolam and 30 mg diazepam over five minutes. Frequent arterial blood samples were collected for up to two hours and venous blood samples were collected for up to 24 hours for midazolam and ten days for diazepam. A gas chromatography assay was used to determine the plasma concentrations of midazolam and diazepam. The im absorption profiles were estimated using constrained least-squares deconvolution. RESULTS: There were substantial intersubject variabilities in the estimated pharmacokinetic parameters (volume and clearances) of intravenous midazolam and diazepam. The mean (+/-sd) time to peak plasma concentration (Cmax) was shorter for im midazolam (17.5 +/- 6.5 min) relative to diazepam (33.8 +/- 7.5 min). The mean (+sd) time to peak absorption rate was also shorter for midazolam (9 +/- 2 vs 13.8 +/- 7.5 min). The peak rate of absorption was identical (0.18 mg. min-1) and bioavailability was 1.0 for both drugs. CONCLUSIONS: We conclude that midazolam has more rapid absorption than diazepam following im administration.


This article has been cited by other articles:


Home page
 J Clin PharmacolHome page
C. Lehmann and G. L. Wannarka
Bioavailability and Dose Proportionality of Intramuscular Diazepam Administered by Autoinjector
J. Clin. Pharmacol., April 1, 2008; 48(4): 436 - 444.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. Vardi, H. Berkenstadt, I. Levin, A. Bentencur, and A. Ziv
Intraosseous Vascular Access in the Treatment of Chemical Warfare Casualties Assessed by Advanced Simulation: Proposed Alteration of Treatment Protocol
Anesth. Analg., June 1, 2004; 98(6): 1753 - 1758.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the Canadian Anesthesiologists' Society.