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Canadian Journal of Anesthesia, Vol 45, 949-953, Copyright © 1998 by Canadian Anesthesiologists' Society

ARTICLES

Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane

LK Ti, HL Pua and TL Lee
Department of Anaesthesia, National University Hospital, Singapore. anatilk@nus.edu.sg

PURPOSE: To evaluate whether isoflurane is as suitable as sevoflurane for the single vital capacity breath (VCB) method of inhalational induction in patients premedicated with midazolam. METHODS: A randomised, controlled, double-blind study involving 67 ASA I-II patients aged between 18-50 yr undergoing elective surgery under general anaesthesia. All participants received premedication with 0.03 mg.kg-1 midazolam i.v. Using a primed circle absorber circuit, inhalational induction of anaesthesia was performed with the single VCB method using either isoflurane 3.5% or sevoflurane 7.5% in nitrous oxide 67% in oxygen, representing approximately equivalent MAC-multiples of 3.6 MAC. Isoflurane was compared with sevoflurane in terms of rapidity, efficacy, safety and acceptability of induction. RESULTS: With the single VCB method, sevoflurane produced a faster (45 +/- 21 vs 71 +/- 22 sec, P < 0.01), more successful (100% vs 75.8%, P < 0.01) induction of anaesthesia, with fewer induction-related complications (11.8% vs 84.8%, P < 0.01) than did isoflurane. There was also greater patient acceptability of induction with sevoflurane (76.4% vs 42.4%, P < 0.05). CONCLUSION: In adults given midazolam premedication, isoflurane is not as suitable as sevoflurane for single VCB inhalational anaesthetic induction technique as it is associated with slower, more complicated induction and less patient acceptability.


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S. Yogendran, A. Prabhu, A. Hendy, G. McGuire, C. Imarengiaye, J. Wong, and F. Chung
Vital capacity and patient controlled sevoflurane inhalation result in similar induction characteristics: [L'inhalation de sevoflurane a capacite vitale et l'inhalation autocontrolee induisent l'anesthesie de facon similaire]
Can J Anesth, January 1, 2005; 52(1): 45 - 49.
[Abstract] [Full Text] [PDF]


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Copyright © 1998 by the Canadian Anesthesiologists' Society.