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Canadian Journal of Anesthesia, Vol 45, 1054-1060, Copyright © 1998 by Canadian Anesthesiologists' Society

ARTICLES

Bupivacaine 0.125% produces motor block and weakness with fentanyl epidural analgesia in children

AS Carr, DW Fear, N Sikich and B Bissonnette
Department of Anaesthesia, Hospital for Sick Children, Toronto, Ontario, Canada. alison.carr@phnt.swest.nhs.uk

PURPOSE: Epidural infusions of fentanyl (2 micrograms.ml-1) alone or combined with bupivacaine 0.125% were compared for perioperative analgesia, motor block and other side-effects in children who underwent urological surgery. METHODS: In a prospective, double-blind study, 42 children, ASA I-II, 1-16 yr, were randomly allocated to receive either epidural F (fentanyl bolus 2 micrograms.kg-1 in 0.5 ml.kg-1 saline followed by 2 micrograms.ml-1 fentanyl infusion) or epidural F-B (fentanyl bolus 2 micrograms.kg-1 in 0.5 ml.kg-1 bupivacaine 0.25% followed by 2 micrograms.ml-1 fentanyl infusion in bupivacaine 0.125%) after induction of general anaesthesia. Adequacy of analgesia, lower limb motor block and side-effects were assessed four hourly postoperatively. RESULTS: Both infusion regimens provided excellent analgesia (median objective pain scores = 0). Epidural infusion rates were similar in the F (0.29 +/- 0.07 ml.kg-1.hr-1) and F-B (0.26 +/- 0.05 ml.kg-1.hr-1) groups. Three children in the F group and all children in the F-B group developed lower limb weakness. (P < 0.05) Bromage scores were different in the F group (median 0, range 0-0.66) compared with the F-B group (median 0.33, range 0-1) (P < 0.001). Other side-effects did not differ. CONCLUSION: Postoperative epidural fentanyl infusion provides equipotent analgesia to administration of a solution including both fentanyl and bupivacaine 0.125% and causes less lower limb weakness. No reduction in the fentanyl requirement resulted from the addition of bupivacaine 0.125%.


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F. Reinoso-Barbero, B. Saavedra, S. Hervilla, J. de Vicente, B. Tabares, and M. S. Gomez-Criado
Lidocaine with fentanyl, compared to morphine, marginally improves postoperative epidural analgesia in children : [Une combinaison de lidocaine et de fentanyl, comparee a la morphine, ameliore peu l'analgesie peridurale postoperatoire chez les enfants]
Can J Anesth, January 1, 2002; 49(1): 67 - 71.
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Copyright © 1998 by the Canadian Anesthesiologists' Society.