CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Komatsu, H.
Right arrow Articles by Mitsuhata, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Komatsu, H.
Right arrow Articles by Mitsuhata, H.

Canadian Journal of Anesthesia, Vol 45, 1186-1189, Copyright © 1998 by Canadian Anesthesiologists' Society

ARTICLES

Systemic hypotensive response to protamine following chronic inhibition of nitric oxide synthase in rats

H Komatsu, K Enzan, S Matsuura, S Kurosawa and H Mitsuhata
Department of Anesthesiology, Hiraga General Hospital, Japan.

PURPOSE: The aims of the present studies were to determine whether the systemic hypotensive response to protamine was modified in rats pre-treated for two weeks with the nitric oxide synthase inhibitor, NG-nitro-L-arginine-methyl ester (L-NAME), and to evaluate the inhibitory effect of heparin on the systemic hypotensive response to protamine in vivo. METHODS: Male rats were randomly assigned into four groups. Normal saline 12 microliters.day-1, D-NAME (an inactive enantiomer of L-NAME), 10 mg.kg-1, L-NAME, 1 or 10 mg.kg-1.day-1 i.p. was administered for two weeks and the haemodynamic changes were measured after protamine administration. In another experiment, male rats were assigned to two groups. In one, the heparin group, protamine was administered after heparin had been administered and in the other, protamine group, protamine alone was administered. RESULTS: L-NAME inhibited the decrease in systemic arterial pressure after protamine administration (P < 0.05), but D-NAME had no effect. Also, heparin reduced the decrease in systemic arterial pressure after protamine (P < 0.05). CONCLUSION: Nitric oxide is mainly responsible for mediation of the systemic hypotensive response to protamine which is also reduced by heparin.


This article has been cited by other articles:


Home page
 Canadian J. AnesthesiaHome page
K. Takakura, M. Mizogami, and S. Fukuda
Protamine sulfate causes endothelium-independent vasorelaxation via inducible nitric oxide synthase pathway: [Le sulfate de protamine cause un vasorelachement independant de l'endothelium par la voie de l'oxyde nitrique synthase inductible]
Can J Anesth, February 1, 2006; 53(2): 162 - 167.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the Canadian Anesthesiologists' Society.