CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gilron, I.
Right arrow Articles by Varin, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gilron, I.
Right arrow Articles by Varin, F.

Canadian Journal of Anesthesia, Vol 45, 115-121, Copyright © 1998 by Canadian Anesthesiologists' Society

ARTICLES

40 Hz auditory steady-state response and EEG spectral edge frequency during sufentanil anaesthesia

I Gilron, G Plourde, W Marcantoni and F Varin
Clinical Trials Unit, NIDR, National Institutes of Health, Bethesda, MD 20892, USA.

PURPOSE: The auditory steady-state evoked response (ASSR) is an evoked potential which provides a sensitive measure of the effects of general anaesthetics on the brain. We used pharmacokinetic-pharmacodynamic (PK-PD) modelling to compare the effects of sufentanil on the amplitude of the ASSR with its effect on spectral edge frequency (SEF) of the electroencephalogram. METHODS: Nine patients scheduled for elective cardiac surgery participated. Midazolam (70 micrograms.kg-1 i.m.) was given 60 min before entering the operating room. Anaesthesia was induced with 5 micrograms.kg-1 sufentanil at a rate of 0.83 microgram.kg-1.min-1. The ASSR, SEF and plasma sufentanil concentrations were measured for 30 min after induction of anaesthesia before surgery. The half-life between the central and effect site compartments (t1/2Keo), the 50% inhibitory concentration (IC50) and the slope factor (gamma) were computed. RESULTS: The amplitude of the ASSR increased during the first three minutes of infusion of sufentanil by up to 40%. This was followed by a rapid decrease between the fourth and fifth minutes to 16% of baseline. The SEF decreased progressively during the first five minutes of infusion to 18% of baseline. Both measures subsequently showed modest recovery. The parameters gamma, IC50 and t1/2Keo for ASSR were (mean +/- SD) 6.0 +/- 3.7, 2.1 +/- 1.2 ng.ml-1 and 7.3 +/- 2.4 min. For SEF the values were 5.9 +/- 5.2, 1.4 +/- 0.7 ng.ml-1 (P < 0.05 compared with ASSR) and 6.8 +/- 2.4 min. CONCLUSION: The sensitivity of ASSR to sufentanil is less than that of the SEF.


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
J. W. Sleigh, D. A. Steyn-Ross, M. L. Steyn-Ross, M. L. Williams, and P. Smith
Comparison of changes in electroencephalographic measures during induction of general anaesthesia: influence of the gamma frequency band and electromyogram signal
Br. J. Anaesth., January 1, 2001; 86(1): 50 - 58.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the Canadian Anesthesiologists' Society.