| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Canadian Journal of Anesthesia, Vol 45, 429-434, Copyright © 1998 by Canadian Anesthesiologists' Society
ARTICLES |
M Beaussier, H Deriaz, Z Abdelahim, F Aissa and A Lienhart
Departement d'Anesthesie-Reanimation chirurgicale, Hopital St-Antoine, Paris, France.
PURPOSE: Increasing the duration of exposure could lead to amplification of the pharmacokinetic differences between halogenated anaesthetic agents. The aim of our study was to compare anaesthesia recovery after desflurane and isoflurane, administered for more than three hours. METHODS: After informed consent, patients were randomly assigned to either desflurane (n = 15) or isoflurane (n = 15) groups. At the end of surgery, halogenated agents were discontinued and fresh gas flow was increased to 6 l.min-1 oxygen 100%. RESULTS: Mean anaesthesia duration was 292 +/- 63 and 304 +/- 91 min in the desflurane and isoflurane groups respectively. After desflurane and isoflurane discontinuation, the time to opening eyes was 12 +/- 7 and 24 +/- 11 min respectively (P < 0.001); to squeeze fingers at command was 17 +/- 11 and 35 +/- 19 min (P < 0.001); to extubation was 16 +/- 6 and 33 +/- 13 min (P < 0.001); to give their name was 22 +/- 12 and 43 +/- 21 min (P < 0.001); to achieve a Steward score of 6 was 28 +/- 16 and 57 +/- 33 min (P < 0.001), to be fit for discharge from the recovery room was 46 +/- 19 and 81 +/- 37 min (P < 0.003). Ranges of times to reappearance of recovery variables in the desflurane group were less than those after isoflurane (P < 0.05). CONCLUSION: After long duration anaesthesia lasting up to three hours, desflurane allowed recovery and extubation in approximately half the time required by isoflurane. Less variability in results suggests better predictability of recovery with desflurane.
This article has been cited by other articles:
 |
|
 |
|
  G. R. Nordmann, J. A. Read, S. M. Sale, P. A. Stoddart, and A. R. Wolf Emergence and recovery in children after desflurane and isoflurane anaesthesia: effect of anaesthetic duration Br. J. Anaesth., June 1, 2006; 96(6): 779 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. I. Eger II and S. L. Shafer Tutorial: Context-Sensitive Decrement Times for Inhaled Anesthetics Anesth. Analg., September 1, 2005; 101(3): 688 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Neumann, E. I Eger II, and R. B. Weiskopf Solubility of Volatile Anesthetics in Bovine White Matter, Cortical Gray Matter, Thalamus, Hippocampus, and Hypothalamic Area Anesth. Analg., April 1, 2005; 100(4): 1003 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Strum, J. Szenohradszki, W. A. Kaufman, G. J. Anthone, I. L. Manz, and P. D. Lumb Emergence and Recovery Characteristics of Desflurane Versus Sevoflurane in Morbidly Obese Adult Surgical Patients: A Prospective, Randomized Study Anesth. Analg., December 1, 2004; 99(6): 1848 - 1853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Derrode, F. Lebrun, J.-C. Levron, M. Chauvin, and B. Debaene Influence of peroperative opioid on postoperative pain after major abdominal surgery: sufentanil TCI versus remifentanil TCI. A randomized, controlled study Br. J. Anaesth., December 1, 2003; 91(6): 842 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Beaussier, A. Decorps, P. Tilleul, A. Megnigbeto, P. Balladur, and A. Lienhart Desflurane improves the throughput of patients in the PACU. A cost-effectiveness comparison with isoflurane: [L'usage du desflurane permet de reduire l'occupation de la SDR : etude de rentabilite comparee avec l'isoflurane] Can J Anesth, April 1, 2002; 49(4): 339 - 346. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
