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Canadian Journal of Anesthesia, Vol 45, 479-482, Copyright © 1998 by Canadian Anesthesiologists' Society

ARTICLES

Lower oesophageal sphincter tone increases after induction of anaesthesia in pigs with full stomach

JP Tournadre, M Barclay, P Bouletreau and D Chassard
Service d'Anesthesie-Reanimation Hopital de l'Hotel-Dieu, Lyon, France. jptourna@univ-lyon1.fr

PURPOSE: The lower oesophageal sphincter (LOS) is the man mechanism that prevents gastro-oesophageal regurgitation during anaesthesia. The aim of this study was to assess the effect on lower oesophageal sphincter pressure (LOSP) of rapid sequence induction in pigs with full stomachs. METHODS: Lower oesophageal sphincter pressure and oesophageal barrier pressure (BrP = LOSP minus gastric pressure) were measured using a water-perfused manometric catheter method in 12 pigs after gastric filling with 500 ml of liquid nutrient mixture. Six pigs were randomly allocated to receive 5 mg.kg-1 propofol and 3 mg.kg-1 succinylcholine i.v. and six pigs received 8 mg.kg-1 thiopentone and 3 mg.kg-1 succinylcholine i.v. RESULTS: After induction, mean LOSP increased during the period with fasciculations from 19 +/- 4 mmHg to 28 +/- 5 mmHg in the propofol-succinylcholine group and from 23 +/- 6 mmHg to 36 +/- 7 mmHg in the thiopentone-succinylcholine group. The LOSP remained elevated after the fasciculations. LOSP and BrP were not different between the groups. CONCLUSIONS: Induction of anaesthesia with propofol-succinylcholine or thiopentone-succinylcholine increases LOSP and, consequently, BrP in pigs with a full stomach. This increase begins before fasciculations and remains elevated for the period when intubation would occur.




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Copyright © 1998 by the Canadian Anesthesiologists' Society.